Joe Gardner is a middle school teacher with a love for jazz music. After a successful gig at the Half Note Club, he suddenly gets into an accident that separates his soul from his body and is transported to the You Seminar, a center in which souls develop and gain passions before being transported to a newborn child. Joe must enlist help from the other souls-in-training, like 22, a soul who has spent eons in the You Seminar, in order to get back to Earth.
A hardened mechanic must stay awake and maintain an interstellar ark fleeing the dying planet Earth with a few thousand lucky souls on board... the last of humanity. Unfortunately, humans are not the only passengers. A shapeshifting alien creature has taken residence, its only goal is to kill as many people as possible. The crew must think quickly to stop this menace before it destroys mankind.